Glybenclamide Cas number: 10238-21-8 Molecular Formula：C23H28ClN3O5S
Glybenclamide Cas number: 10238-21-8 Molecular Formula：C23H28ClN3O5S
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Ask Doctor advise firstGlyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1?Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Glyburide also inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.2?Cell permeable.5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]-SULFONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE 5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]SULPHONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE 5-CHLORO-N-[4-(CYCLOHEXYLUREIDOSULFONYL)PHENETHYL]-2-METHOXYBENZAMIDE GIBENCLAMIDE GLIBENCLAMIDE GLYBENCLAMIDE GLYBENZCYCLAMIDE GLYBURIDE LABOTEST-BB LT00244861 MICRONASE N-P-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]BENZENESULFONYL-N'-CYCLOHEXYLUREA 1-((p-(2-(Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-ure 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea 1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea 1-[[p-[2-(chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexyl-Urea 5-chloro-n-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2 Abbenclamide adiab
Melting Point
173-175°C
Density
1.1805 (rough estimate)
storage temp
Inert atmosphere,Room Temperature 2-8°C
solubility
ethanol: soluble2mg/mL
optical activity
N/A
Appearance
White Crystalline Powder
Purity
≥98%
A second generation sulfonylurea with hypoglycemic activity
Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1?Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Glyburide also inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.2?Cell permeable.5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]-SULFONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE 5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]SULPHONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE 5-CHLORO-N-[4-(CYCLOHEXYLUREIDOSULFONYL)PHENETHYL]-2-METHOXYBENZAMIDE GIBENCLAMIDE GLIBENCLAMIDE GLYBENCLAMIDE GLYBENZCYCLAMIDE GLYBURIDE LABOTEST-BB LT00244861 MICRONASE N-P-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]BENZENESULFONYL-N'-CYCLOHEXYLUREA 1-((p-(2-(Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-ure 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea 1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea 1-[[p-[2-(chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexyl-Urea 5-chloro-n-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2 Abbenclamide adiab
